Since its initial publication in 1950, Slavery in Alabama remains the only comprehensive statewide study of the institution of slavery in Alabama. Sellers concentrates on examining the social and economic aspects of how slavery operated in the state. After a brief discussion of slavery under imperial rulers of the colonial and territorial periods, Sellers focuses on the transplantation of the slavery system from the Atlantic seaboard states to Alabama.
Sellers used the primary sources available to him, including government documents, county and city records, personal papers, church records, and newspapers. His discussions of the church and the slave, and his treatment of the proslavery defense, deepen the comprehensiveness of his study. His two sections of photographs are special touches showing former slaves and churches with slave galleries.